[:es]Antonio Arroyo (Elche University Hospital, Miguel Hernández University), Luis Sánchez‐Guillén, (Elche University Hospital, Miguel Hernández University), Pedro Antonio Parra (Reina Sofía University Hospital, UCAM Universidad Católica de Murcia), Luis García‐Catalá (Elche University Hospital, Miguel Hernández University), Emilio Peña‐Ros (Reina Sofía University Hospital, UCAM Universidad Católica de Murcia), Manuel Ferrer‐Márquez (Torrecardenas University Hospital), Carmen Nofuentes Riera (San Juan University Hospital, Miguel Hernandez University), Xavier Barber‐Valles (Center of Operations Research, Miguel Hernandez University) and Manuel Romero‐Simó (Alicante University General Hospital, Miguel Hernandez University).
Background and Objectives: To validate and analyze the results of intralesional photodynamic therapy in the treatment of complex anal fistula.
Study Design/Materials and Methods: This prospective multicentric observational study enrolled patients treated for complex anal fistula who underwent intralesional photodynamic therapy (i‐PDT). The included patients were treated from January 2016 to December 2018 with a minimum follow‐up of 1 year to evaluate recurrence, continence and postoperative morbidity. Intralesional 5‐aminolevulinic acid (ALA) gel (2%) was injected directly into the fistula. The internal and external orifices were closed. After an incubation period of 2 hours, the fistula was irradiated using an optical fiber connected to a red laser (Multidiode 630 PDT) operating at 1 W/cm for 3 minutes (180 J).
Results: In total, 49 patients were included (61.2% male). The mean age was 48 years, and the mean duration of fistula was 13 months. Of the fistulas included, 75.5% were medium transphincteric, and 24.5% were high transphincteric. The median fistula length was 4 ± 1,14 cm (range: 3–5). A total of 41 patients (83.7%) had a previous history of fistula surgery. Preoperatively, some degree of anal incontinence was found in 5 patients (10.2%). No center reported any other procedure‐related complications intraoperatively. Phototoxicity was found in one patient. In the first 48 hours after the procedure, fever was reported in 2 patients (4%). At the end of follow‐up, total healing was observed in 32/49 patients (65.3%). No patient reported new incontinence postoperatively.
Keywords. complex anal fistula; surgery; photodynamic therapy; incontinence; proctology[:]
Scientific articles
N. Allouch, Luis A. Guardiola, & A. Meca (2024). Measuring productivity in networks: A game-theoretic approach. Socio-Economic Planning Sciences, 91, 101783.
N. Allouch (University of Kent – School of Economics), Luis A. Guardiola (Departamento de Métodos Cuantitativos para la Economía y Empresa, Universidad de Murcia), Ana Meca (I.U. Centro de Investigación Operativa, Universidad Miguel Hernández de Elche) Abstract: Measuring individual productivity (or equivalently distributing the overall productivity) in a network structure of workers displaying peer effects has been [...]