Conferencia de la Profa. Lidia Mínguez

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Title: Urinary triclosan concentrations and diminished ovarian reserve among women from a fertility clinic.
Speaker: Lidia Mínguez Alarcón (Universidad de Harvard)
Date: 25/10/2017, 12:00h
Location: Sala de Seminarios (Edificio Torretamarit)
Abstract:

Background/Aim: Triclosan, an endocrine disrupting chemical used as an antibacterial in personal care and consumer products, has shown estrogenic activity in experimental studies. There are limited human studies on reproductive health effects of triclosan. The objective of this study was to prospectively investigate the association between urinary triclosan concentrations and antral follicle count (AFC), a well-accepted marker of ovarian reserve, among women from a fertility center.

Methods: This analysis included 109 women in the Environmental and Reproductive Health (EARTH) Study who provided at least one urine sample prior to the measurement of AFC, between 2007 and 2016. We quantified urinary triclosan concentrations by tandem mass spectrometry and measured AFC through transvaginal ultrasonography on the 3rd day of an unstimulated menstrual cycle or on the 3rd day of a progesterone withdrawal bleed. Poisson regression models were used to estimate the associations of specific gravity (SG)-adjusted urinary triclosan concentrations (as continuous in log_e scale) with AFC adjusted for age, body mass index (BMI), year of sample collection, physical activity and baseline infertility diagnosis.

Results: The median (interquartile range, IQR) of the SG-adjusted urinary triclosan concentrations for the 225 samples provided by the 109 women was 7.9 (3.0, 33.6) µg/L. Women had median (IQR) AFC of 13 (8, 18). In unadjusted models, one log_e unit increase in SG-adjusted urinary triclosan concentrations was associated with a 3% decrease (95% CI= -5%, -2%) in AFC (p-value=0.04). This association strengthened after adjustment for covariates (-4%, 95% CI= -7%, -1%, p-value=0.009). Specifically, women in the 75^th percentile of exposure (33.6 µg/L) had a 6.6% decrease in AFC compared with women in the 25^th percentile (3.0 µg/L).

Conclusion: SG-adjusted urinary triclosan concentrations were inversely associated with AFC in women seeking care at a fertility center.

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