{"id":25468,"date":"2021-01-18T10:54:24","date_gmt":"2021-01-18T09:54:24","guid":{"rendered":"https:\/\/cio.umh.es\/?p=25468"},"modified":"2022-01-18T12:28:37","modified_gmt":"2022-01-18T11:28:37","slug":"ballester-navarro-p-martinez-madrid-m-j-javaloyes-sanchis-a-belda-canto-c-aguilar-v-inda-m-d-m-richdale-a-l-muriel-j-morales-d-peiro-a-m-2021-interplay-of-circadian-clock","status":"publish","type":"post","link":"https:\/\/cio.umh.es\/en\/2021\/01\/18\/ballester-navarro-p-martinez-madrid-m-j-javaloyes-sanchis-a-belda-canto-c-aguilar-v-inda-m-d-m-richdale-a-l-muriel-j-morales-d-peiro-a-m-2021-interplay-of-circadian-clock\/","title":{"rendered":"Ballester-Navarro, P., Mart\u00ednez-Madrid, M.J., Javaloyes-Sanch\u00eds, A., Belda-Cant\u00f3 C., Aguilar V., Inda M.-D.-M., Richdale A.L., Muriel J., Morales, D., Peir\u00f3, A.M. (2021) \u00abInterplay of circadian clock and melatonin pathway gene variants in adults with autism, intellectual disability and sleep problems\u00bb, Research in Autism Spectrum Disorders, 81:101715"},"content":{"rendered":"<p class=\"AuthorHeader-module__syvlN margin-size-4-t\" style=\"text-align: justify\"><strong>Pura Ballester, Mar\u00eda Del Mar Inda, Javier Muriel, Ana M. Peir\u00f3 <\/strong><strong>(Neuropharmacology on Pain (NED), Alicante Institute for Health and Biomedical Research (ISABIAL-FISABIO Foundation)), Mar\u00eda Jos\u00e9 Mart\u00ednez Madrid (Chronobiology Laboratory, University of Murcia), Auxiliadora Javaloyes Sanch\u00eds (EDUCATEA, Education Center for Children and Adolescents with Autism, Mental Health Problems and Behavioural Disorders, Alicante), C\u00e9sar Belda Cant\u00f3 (Infanta Leonor Autism Center, Alicante), V\u00edctor Aguilar (San Rafael Autism Center, Santa Faz), Amanda L. Richdale (Olga Tennison Autism Research Centre, School of Psychology &amp; Public Health, La Trobe University, Melbourne) and Domingo Morales (Operations Research Center, University Miguel Hern\u00e1ndez of Elche)\u00a0<\/strong><\/p>\n<p class=\"AuthorHeader-module__syvlN margin-size-4-t\" style=\"text-align: justify\"><strong>Abstract: <\/strong>Background: People diagnosed with Autism Spectrum Disorder and intellectual disability (ID) usually experience sleep problems, where circadian clock and melatonin pathway genes may play a role. Method: Our aim was to analyze the influence of genetic variants PER1, ASMT, NPAS2, and MTNR1A by MassARRAY, in sleep-wake rhythms in a group of autistic adults with ID, cases (n = 83) and controls (n = 25). Sleep-wake rhythms were evaluated with ambulatory circadian monitoring. Results: In autistic cases (age 18\u221241years), PER1 rs6416892-GG and ASMT rs5989681-GG genotypes had a better sleep pattern according to sleep onset latency and awakenings; together with a worse sleep and\/or temperature rhythm. Furthermore, diurnal temperature values were affected by NPAS2 rs1811399-CC genotype. Conclusions: Normal and abnormal sleep-wake rhythms could be related to circadian clock (PER1) and melatonin pathway (ASMT) gene variants. There is a need for further research to translate this data into clinical decisions or risk profiles.<\/p>","protected":false},"excerpt":{"rendered":"<p>Pura Ballester, Mar\u00eda Del Mar Inda, Javier Muriel, Ana M. Peir\u00f3 (Neuropharmacology on Pain (NED), Alicante Institute for Health and Biomedical Research (ISABIAL-FISABIO Foundation)), Mar\u00eda Jos\u00e9 Mart\u00ednez Madrid (Chronobiology Laboratory, University of Murcia), Auxiliadora Javaloyes Sanch\u00eds (EDUCATEA, Education Center for Children and Adolescents with Autism, Mental Health Problems and Behavioural Disorders, Alicante), C\u00e9sar Belda Cant\u00f3 [&#8230;]<\/p>","protected":false},"author":5675,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_links_to":"","_links_to_target":""},"categories":[369888],"tags":[],"_links":{"self":[{"href":"https:\/\/cio.umh.es\/en\/wp-json\/wp\/v2\/posts\/25468"}],"collection":[{"href":"https:\/\/cio.umh.es\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cio.umh.es\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cio.umh.es\/en\/wp-json\/wp\/v2\/users\/5675"}],"replies":[{"embeddable":true,"href":"https:\/\/cio.umh.es\/en\/wp-json\/wp\/v2\/comments?post=25468"}],"version-history":[{"count":0,"href":"https:\/\/cio.umh.es\/en\/wp-json\/wp\/v2\/posts\/25468\/revisions"}],"wp:attachment":[{"href":"https:\/\/cio.umh.es\/en\/wp-json\/wp\/v2\/media?parent=25468"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cio.umh.es\/en\/wp-json\/wp\/v2\/categories?post=25468"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cio.umh.es\/en\/wp-json\/wp\/v2\/tags?post=25468"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}