{"id":25294,"date":"2021-10-14T10:19:07","date_gmt":"2021-10-14T08:19:07","guid":{"rendered":"https:\/\/cio.umh.es\/?p=25294"},"modified":"2022-01-14T10:25:58","modified_gmt":"2022-01-14T09:25:58","slug":"sanchez-guillen-l-soriano-irigaray-l-lopez-rodriguez-arias-f-barber-x-murcia-a-alcaide-m-j-aranaz-ostariz-v-soler-silva-a-navarro-ruiz-a-arroyo-a-2021-effect-of-early-perip","status":"publish","type":"post","link":"https:\/\/cio.umh.es\/en\/2021\/10\/14\/sanchez-guillen-l-soriano-irigaray-l-lopez-rodriguez-arias-f-barber-x-murcia-a-alcaide-m-j-aranaz-ostariz-v-soler-silva-a-navarro-ruiz-a-arroyo-a-2021-effect-of-early-perip\/","title":{"rendered":"S\u00e1nchez-Guill\u00e9n, L., Soriano-Irigaray, L., L\u00f3pez-Rodr\u00edguez-arias, F., Barber X., Murcia A., Alcaide M.J., Aranaz-Ost\u00e1riz V., Soler-Silva \u00c1., Navarro-Ruiz, A., Arroyo, A. (2021) \u00abEffect of early peripheral parenteral nutrition support in an enhanced recovery program for colorectal cancer surgery: A randomized open trial\u00bb, Journal of Clinical Medicine, 10 (16):3647"},"content":{"rendered":"<p class=\"AuthorHeader-module__syvlN margin-size-4-t\" style=\"text-align: justify\"><strong style=\"font-size: 18px\">Lu\u00eds S\u00e1nchez-Guill\u00e9n, Francisco L\u00f3pez-Rodr\u00edguez-Arias, Mar\u00eda Jos\u00e9 Alcaide, Ver\u00f3nica Aranaz-Ost\u00e1riz, \u00c1lvaro Soler-Silva, Antonio Arroyo (Colorectal Unit, Department of General Surgery, Elche University Hospital, Miguel Hernandez University), Leticia Soriano-Irigaray, Ana Cristina Murcia-L\u00f3pez, Andr\u00e9s Navarro-Ruiz (Department of Pharmacy, Elche University Hospital-FISABIO ) and Xavier Barber (<em>University Miguel Hern\u00e1ndez of Elche<\/em>)<\/strong><\/p>\n<p style=\"text-align: justify\"><strong>Abstract:\u00a0<\/strong><span>Background: Peripheral parenteral nutrition allows repletion of acute nutrient deficiencies and could prevent further nutrition deficits before and after colorectal surgery. A randomized open study was performed to evaluate the effect of perioperative peripheral parenteral nutrition (PPN) support on postoperative morbidity after colorectal cancer surgery within an enhanced recovery program. Methods: Patients were randomized into two groups: peripheral parenteral nutrition (PPN) (with Peri-Olimel N4-E) versus conventional fluid therapy (FT). Ninety-day postoperative complications, laboratory parameters, length of hospital stay, and compliance with the ERAS protocol were assessed. Results: A total of 158 patients were analysed. The overall 90-day complication rate was 38.6% (61 patients), and 24 patients had major complications (Clavien\u2013Dindo III\u2013V) (15.2%). In the multivariate analysis, the intervention (PPN vs. FC) showed a protective effect against postoperative complications (p = 0.0031, OR = 0.2 (CI: 0.08\u20130.87)). Following ordinal regression, PPN and early oral tolerance showed a protective effect, being less likely to develop complications or to move from minor to major complications. In patients with low compliance to ERAS during the first postoperative day, PPN showed a protective effect, preventing 28% of morbidity. Conclusions: Perioperative peripheral parenteral nutrition (PPN) support with Peri-Olimel N4-E in colorectal cancer surgery associated with early oral intake could reduce postoperative complications.\u00a0<\/span><\/p>","protected":false},"excerpt":{"rendered":"<p>Lu\u00eds S\u00e1nchez-Guill\u00e9n, Francisco L\u00f3pez-Rodr\u00edguez-Arias, Mar\u00eda Jos\u00e9 Alcaide, Ver\u00f3nica Aranaz-Ost\u00e1riz, \u00c1lvaro Soler-Silva, Antonio Arroyo (Colorectal Unit, Department of General Surgery, Elche University Hospital, Miguel Hernandez University), Leticia Soriano-Irigaray, Ana Cristina Murcia-L\u00f3pez, Andr\u00e9s Navarro-Ruiz (Department of Pharmacy, Elche University Hospital-FISABIO ) and Xavier Barber (University Miguel Hern\u00e1ndez of Elche)<br \/>\nAbstract:\u00a0Background: Peripheral parenteral nutrition allows repletion of acute nutrient [&#8230;]<\/p>","protected":false},"author":5675,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_links_to":"","_links_to_target":""},"categories":[369888],"tags":[],"_links":{"self":[{"href":"https:\/\/cio.umh.es\/en\/wp-json\/wp\/v2\/posts\/25294"}],"collection":[{"href":"https:\/\/cio.umh.es\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cio.umh.es\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cio.umh.es\/en\/wp-json\/wp\/v2\/users\/5675"}],"replies":[{"embeddable":true,"href":"https:\/\/cio.umh.es\/en\/wp-json\/wp\/v2\/comments?post=25294"}],"version-history":[{"count":0,"href":"https:\/\/cio.umh.es\/en\/wp-json\/wp\/v2\/posts\/25294\/revisions"}],"wp:attachment":[{"href":"https:\/\/cio.umh.es\/en\/wp-json\/wp\/v2\/media?parent=25294"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cio.umh.es\/en\/wp-json\/wp\/v2\/categories?post=25294"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cio.umh.es\/en\/wp-json\/wp\/v2\/tags?post=25294"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}