{"id":16586,"date":"2020-05-05T10:46:55","date_gmt":"2020-05-05T10:46:55","guid":{"rendered":"http:\/\/cio.edu.umh.es\/?p=16586"},"modified":"2021-07-22T09:50:10","modified_gmt":"2021-07-22T07:50:10","slug":"photodynamic-therapy-for-the-treatment-of-complex-anal-fistula-2019-wiley-periodicals-inc","status":"publish","type":"post","link":"https:\/\/cio.umh.es\/en\/2020\/05\/05\/photodynamic-therapy-for-the-treatment-of-complex-anal-fistula-2019-wiley-periodicals-inc\/","title":{"rendered":"Photodynamic Therapy for the Treatment of Complex Anal Fistula, 2019 Wiley Periodicals, Inc."},"content":{"rendered":"<p>[:es]<strong>Antonio Arroyo<\/strong> (<em>Elche University Hospital, Miguel Hern\u00e1ndez University<\/em>),\u00a0<strong>Luis S\u00e1nchez\u2010Guill\u00e9n, (<\/strong><em>Elche University Hospital, Miguel Hern\u00e1ndez University<\/em>),\u00a0<strong>Pedro Antonio Parra\u00a0<\/strong>(<em>Reina Sof\u00eda University Hospital, UCAM Universidad Cat\u00f3lica de Murcia<\/em>),\u00a0<strong>Luis Garc\u00eda\u2010Catal\u00e1\u00a0<\/strong>(<em>Elche University Hospital, Miguel Hern\u00e1ndez University<\/em>),\u00a0<strong>Emilio Pe\u00f1a\u2010Ros\u00a0<\/strong>(<em>Reina Sof\u00eda University Hospital, UCAM Universidad Cat\u00f3lica de Murcia),\u00a0<\/em><strong>Manuel Ferrer\u2010M\u00e1rquez<\/strong><em> (Torrecardenas University Hospital),\u00a0<\/em><strong>Carmen Nofuentes Riera<\/strong><em> (San Juan University Hospital, Miguel Hernandez University),\u00a0<\/em><strong>Xavier Barber\u2010Valles<\/strong><em> (Center of Operations Research, Miguel Hernandez University)\u00a0<\/em>and\u00a0<strong>Manuel Romero\u2010Sim\u00f3 <\/strong>(<em>Alicante University General Hospital, Miguel Hernandez University<\/em>).<br \/>\n<strong>Background and Objectives:<\/strong> To validate and analyze the results of intralesional photodynamic therapy in the treatment of complex anal fistula.<br \/>\n<strong>Study Design\/Materials and Methods:<\/strong> This prospective multicentric observational study enrolled patients treated for complex anal fistula who underwent intralesional photodynamic therapy (i\u2010PDT). The included patients were treated from January 2016 to December 2018 with a minimum follow\u2010up of 1 year to evaluate recurrence, continence and postoperative morbidity. Intralesional 5\u2010aminolevulinic acid (ALA) gel (2%) was injected directly into the fistula. The internal and external orifices were closed. After an incubation period of 2 hours, the fistula was irradiated using an optical fiber connected to a red laser (Multidiode 630 PDT) operating at 1 W\/cm for 3 minutes (180 J).<br \/>\n<strong>Results:<\/strong> In total, 49 patients were included (61.2% male). The mean age was 48 years, and the mean duration of fistula was 13 months. Of the fistulas included, 75.5% were medium transphincteric, and 24.5% were high transphincteric. The median fistula length was 4 \u00b1 1,14 cm (range: 3\u20135). A total of 41 patients (83.7%) had a previous history of fistula surgery. Preoperatively, some degree of anal incontinence was found in 5 patients (10.2%). No center reported any other procedure\u2010related complications intraoperatively. Phototoxicity was found in one patient. In the first 48 hours after the procedure, fever was reported in 2 patients (4%). At the end of follow\u2010up, total healing was observed in 32\/49 patients (65.3%). No patient reported new incontinence postoperatively.<br \/>\n<strong>Keywords.\u00a0<\/strong>\u00a0complex anal fistula;\u00a0surgery; photodynamic therapy; incontinence; proctology[:]<\/p>","protected":false},"excerpt":{"rendered":"<p>[:es]Antonio Arroyo (Elche University Hospital, Miguel Hern\u00e1ndez University),\u00a0Luis S\u00e1nchez\u2010Guill\u00e9n, (Elche University Hospital, Miguel Hern\u00e1ndez University),\u00a0Pedro Antonio Parra\u00a0(Reina Sof\u00eda University Hospital, UCAM Universidad Cat\u00f3lica de Murcia),\u00a0Luis Garc\u00eda\u2010Catal\u00e1\u00a0(Elche University Hospital, Miguel Hern\u00e1ndez University),\u00a0Emilio Pe\u00f1a\u2010Ros\u00a0(Reina Sof\u00eda University Hospital, UCAM Universidad Cat\u00f3lica de Murcia),\u00a0Manuel Ferrer\u2010M\u00e1rquez (Torrecardenas University Hospital),\u00a0Carmen Nofuentes Riera (San Juan University Hospital, Miguel Hernandez University),\u00a0Xavier Barber\u2010Valles (Center [&#8230;]<\/p>","protected":false},"author":6202,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_links_to":"","_links_to_target":""},"categories":[369888],"tags":[],"_links":{"self":[{"href":"https:\/\/cio.umh.es\/en\/wp-json\/wp\/v2\/posts\/16586"}],"collection":[{"href":"https:\/\/cio.umh.es\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cio.umh.es\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cio.umh.es\/en\/wp-json\/wp\/v2\/users\/6202"}],"replies":[{"embeddable":true,"href":"https:\/\/cio.umh.es\/en\/wp-json\/wp\/v2\/comments?post=16586"}],"version-history":[{"count":0,"href":"https:\/\/cio.umh.es\/en\/wp-json\/wp\/v2\/posts\/16586\/revisions"}],"wp:attachment":[{"href":"https:\/\/cio.umh.es\/en\/wp-json\/wp\/v2\/media?parent=16586"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cio.umh.es\/en\/wp-json\/wp\/v2\/categories?post=16586"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cio.umh.es\/en\/wp-json\/wp\/v2\/tags?post=16586"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}